김창훈 / KIM, Chang-Hoon
부교수

Department / Institute / Center :
Otorhinolaryngology(이비인후과학교실)
The Airway Mucus Institute (기도점액연구소)

Contact Information

Phone : +82-2-2228-3627 Email entman@yuhs.ac Website

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1992
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 2004
Overseas Training (Institute, Supervisor) 1. MD Anderson Cancer Center, Toracic Head & Neck Medical Oncology, Jaseok P. Koo, PhD, 2002-2003
2. The Scripps Research Institute, Immunology, Wendy L. Havran, PhD, 2006-2008

Professional Societies and current positions

대한비과학회, 총무이사, 2011-현재
대한이비인후과학회, 수련 및 학술 위원, 20010-현재

Research Area(s)

Basic research, Translational research, Clinical research
Research Field Role of hypoxia on upper airway disorders
Role of mucins in upper airway
Pathophysiologic mechanism of allergic rhinitis
Mucosal innate immunity of upper airway epithelium
Role of resident T cells in upper airway
Diseases Rhinosinusitis, Allergic rhinitis, Upper airway viral disease
Possible Collaboration Role of hypoxia on upper airway disorders
Role of mucins in upper airway
Pathophysiologic mechanism of allergic rhinitis
Mucosal innate immunity of upper airway epithelium
Role of resident T cells in upper airway

Research Methods

Primary human nasal epithelial culture (ALI technique)
siRNA, shRNA, lentivirus, adenoviral gene transfer
Confocal microscopy, immunohistochemistry
FACS analysis
Chromatin immunoprecipitation, EMSA, luciferase assay
Conditional Knock-out animal experiment

Lab.

연구실사이트 바로가기
Location of Office 안이비인후과병원 4층 403호
Location of Lab. 암센터 1층 “생체방어연구센터”
Contact person Name: 안영은 / Tel: 2228-2660 / E-mail: mucotech@yuhs.ac

Major Published Articles and Books

1. Characterization and TCR variable region gene use of mouse resident nasal  T lymphocytes. J Leukocyte Biol 2008 Nov 1;84(5):1259-1263. (4.128)
2. Expression and regulation of PLUNC in human nasal epithelium. Acta Otolaryngol 2006 Oct;126(10):1073-1078.
3. MUC8 as a ciliated cell marker in human nasal epithelium. Acta Otolaryngol 2005 Jan;125(1):76-81.
4. Membrane-specific expression of functional purinergic receptors in normal human nasal epithelial cells. Am J Physiol Lung Cell Mol Physiol 2004 Oct;287(4):L835-42.
5. Proteomic and transcriptomic analysis of interleukin-1β treated lung carcinoma cell line. Proteomics 2003 Dec;3(12):2454–71.