윤주헌 / YOON, Joo-Heon
교수

Department / Institute / Center :
Research Center for Human Natural Defense System
The Airway Mucus Istitute
생체방어연구센터
기도점액연구소

Contact Information

Phone +82-2-2228-3610 Email jhyoon@yuhs.ac Website

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1982
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 1991
Overseas Training (Institute, Supervisor) Visiting scientist, National Institutes of Environmental Health Sciences, Research Triangle Park, North Carolina, USA, Dr. Paul Nettesheim, 1995-1997

Visiting scientist, Department of Otolaryngology, Kagoshima University, Kagoshima, Japan, 1994 – 1994

Professional Societies and current positions

연세대학교 기도점액연구소 소장, 2004~2012년
한국연구재단 우수연구센터(SRC) 생체방어연구센터 센터장, 2007~현재
Am J Respir Cell Mol Biol Editorial Board, 2009~현재
대한민국 의학한림원 학술위원, 2009~현재
연세대학교 의과대학 학장 , 2010~현재

Research Area(s)

Basic research, Translational research
Research Field Mucosal innate immunity of upper airway epithelium
Role of mucin in upper airway
Regulation of mucin secretion in airway epithelium

Diseases Rhinosinusitis, allergic rhinitis, sinonasal tumor

Possible Collaboration Mucosal innate immunity of upper airway epithelium
Role of mucin in upper airway
Regulation of mucin secretion in airway epithelium

Research Methods

Primary human nasal epithelial culture (ALI technique)
Confocal microscopy, Immunohistochemistry
EMSA, luciferase assay, FACS analysis
Conditional Knock-out animal experiment

Lab.

연구실사이트 바로가기
Location of Office 암센터 1층
Location of Lab. 암센터 1층 생체방어연구센터
Contact person Name: 안영은 / Tel: 2228-2660 / E-mail: mucotech2@yuhs.ac

Major Published Articles and Books

1. House dust mite extract activates apical Cl(-) channels through protease-activated receptor 2 in human airway epithelia. J Cell Biochem 2010;109:1254-63.
2. Upregulation of MUC5AC gene expression by IL-4 through CREB in human airway epithelial cells. J Cell Biochem 2009;108:974-981
3. Suppression of Prostaglandin E2-induced MUC5AC overproduction by RGS4 in the airway. Am J Physiol-Lung Cell Mol Physiol 2009;296:L684-92.
4. RGS4 suppresses LPS-induced MUC5AC overexpression in the airway. Am J Respir Cell Mol Biol 2009;41:40-9.
5. Interaction of SOCS3 with NonO attenuates IL-1b-dependent MUC8 gene expression. Biochem Biophys Res Commun 2008;377:946-951.