이진우 / LEE, Jin Woo
교수

Department / Institute / Center :
Department of Orthopaedic Surgery

Contact Information

Phone +82-2-2228-2190 Email ljwos@yuhs.ac Website

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1988
Final Degree (University, Major) Ph.D. from Yonsei University, Graduate School, 1998
Overseas Training (Institute, Supervisor) Research fellow in division of Orthopadic Surgery, Duke University Medical Center, Durham, NC, USA.
Sean P. Scully, MD, PhD 1998-2000

Professional Societies and current positions

Korean Board of Orthopaedic Surgery
Member of the Korean Foot & Ankle Society
Member of the Korean Orthopaedic Research Society
Member of the Orthopaedic Research Society
Member of the American Orthopaedic Foot and Ankle

Research Area(s)

Basic research, Translational research, Clinical research
Research Field Role of STAT5 during osteogenesis of human mesenchymal stem cells
Characterization of microRNA during chondrogenesis
Characterization of human mesenchymal stem cell
Regeneration of articular cartilage defect using mesenchymal stem cell
Diseases Osteoarthritis, Diabetic foot, Foot and ankle disease, Osteoporosis
Possible Collaboration 관절연골 재생을 위한 지지체 발굴 및 세포 생물학적 연구
골다공증 치료를 위한 신약 타겟 발굴 및 small molecule을 이용한 스크리닝
중간엽 줄기세포 노화와 연관된 후성유전학 기전연구
연골재생을 위한 MicroRNA의 기능 분석 및 동물모델을 이용한 최적화 연구

Research Methods

Human, dog, rabbit, and mouse primary MSC isolation and culture
Porcine and human parimay chondrocyte isolation and culture
Differentiation of osteogenesis, adipogenesis and chondrogenesis
siRNA, lentivirus transfer
Confocal microscopy, immunohistochemistry
FACS analysis
Chromatin immunoprecipitation, EMSA, luciferase assay
microRNA technique
Knock-out animal experiment
Regeneration of articular cartilage using rabbit and dog

Lab.

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Location of Office 의대본관 4층 정형외과학 교실
Location of Lab. 에비슨의생명연구센터 (ABMRC) 201호
Contact person Name: 윤동석 / Tel: 2228-0787 / E-mail: dsyoon@yuhs.ac

Major Published Articles and Books

1) SIRT1 Directly Regulates SOX2 to Maintain Self-Renewal and Multipotency in Bone Marrow-Derived Mesenchymal Stem Cells. Dong Suk Yoon, Yoorim Choi, Yeonsue Jang, Moses Lee, Woo Jin Choi, Sung-Hwan Kim, Jin Woo Lee. Stem Cells, 2014 Aug 7. doi: 10.1002/stem.1811. [Epub ahead of print]
2) Interleukin-6 induces the lineage commitment of bone marrow-derived mesenchymal multipotent cells through down-regulation of Sox2 by osteogenic transcription factors. Dong Suk Yoon, Yun Hee Kim, Seulgi Lee, Kyoung-Mi Lee, Kwang Hwan Park, Yeonsue Jang, Jin Woo Lee. FASEB Journal, 28(7):3273-3286, 2014.
3) MicroRNA-495 Inhibits Chondrogenic Differentiation in Human Mesenchymal Stem Cells by Targeting Sox9. Seulgi Lee, Dong Suk Yoon, Seungil Paik, Kyoung-Mi Lee, Yeonsue Jang, Jin Woo Lee. Stem Cells and Development, 23(15): 1798-1808, 2014.
4) In situ recruitment of human BMSCs using chemokines for articular cartilage regeneration. Min Sung Park, Yun Hee Kim, Youngmee Jung, Soo Hyun Kim, Jong Chul Park, Dong Suk Yoon, Sung-hwan Kim, Jin Woo Lee. Cell Transplantation, 2014 Apr 22. [Epub ahead of print]
5) Characterization of different subpopulations from bone marrow-derived mesenchymal stromal cells by alkaline phosphatase expression. Yun Hee Kim, Dong Suk Yoon, Hyun Ok Kim, Jin Woo Lee. Stem Cells and Development, 21:2958-2968, 2012.