이승헌 / LEE, Seung Hun
교수

Department / Institute / Center :
Dermatology
Human barrier research institute

Contact Information

Phone +82-2-2019-3361 Email ydshderm@yuhs.ac Website

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1977
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 1985
Overseas Training (Institute, Supervisor) University of California at San Francisco, USA, Dept. Dermatology
Peter M Elias, MD, PhD, 1989-1990

Professional Societies and current positions

대한피부과학회 부회장, 2009. 10 – 현 재
한국피부장벽학회 명예회장, 2004. 9 – 현 재
인체보호막연구소 소장, 2007. 11 – 현 재
Patron member of Society for Investigative Dermatology

Research Area(s)

Basic research, Translational research, Clinical research
Research Field Pathogenesis of atopic dermatitis
Role of protease/protease-activated receptor-2 in skin barrier function
Role of pH and epidermal calcium ions in skin barrier function
Epidermal tight junction barrier
Diseases Atopic dermatitis, Acne, Skin barrier, Tight junction
Possible Collaboration Protease-activated receptor-2 저해제를 이용한 아토피피부염 및 염증성 피부질환 치료제의 개발
아토피피부염 발병 및 악화의 새로운 기전 연구
Epithelial tight junction 의 기능과 구조에 대한 조절인자 발굴
유전적인 소인이 있는 만성염증성 피부질환인 아토피피부염과 건선에서 프로테옴/지노믹스를 이용한 새로운 disease-related genes의 발굴

Research Methods

Confocal microscopy, immunohistochemistry, immunofluorescence
Electron microscopy
Mouse and human primary keratinocyte isolation and culture
Mouse and human primary sebocyte isolation and culture
Melanocyte and keratinocyte co-culture
Protease activity measurement by in situ zymography
Measurement of Ca2+ mobilization
Real-time reverse transcription-polymerase chain reaction (RT-PCR)
Western blotting
Ion capture cytochemistry
transepidermal water loss (TEWL) measurements

Lab.

연구실사이트 바로가기
Location of Office 강남세브란스병원 별관 9층 피부과교수실
Location of Lab. 강남임상의학연구센터 301호
Contact person Name: 김지민 (통합 7학기) / Tel: 2019-5330 / E-mail: bbonda-jm@hanmail.net

Major Published Articles and Books

1. K6PC-5, a Direct Activator of Sphingosine Kinase 1, Promotes Epidermal Differentiation Through Intracellular Ca2+ Signaling. Hong JH, Youm JK, Kwon MJ, et al. J Invest Dermatol. 128(9), 2166-2178, 2008
2. Protease-activated receptor 2 mediates the expression of inflammatory cytokines, antimicrobial peptides, and matrix metalloproteinases in keratinocytes in response to Propionibacterium acnes. Lee SE, Kim JM, Jeong SK, Jeon JE, Yoon HJ, Jeong MK, Lee SH. Arch Dermatol Res. 2010 Dec;302(10):745-56.
3. Biopositive Effects of Low-Dose UVB on Epidermis: Coordinate upregulation of Antimicrobial Peptides and Permeability Barrier Reinforcement. Hong Seung Pil, Kim Min Jung, Jung Min-young, Jeon Hyerin, Goo Jawoong, Ahn Sung Ku, Lee Seung Hun, Peter M. Elias and Choi Eung Ho. J Invest Dermatol. 128(12): 2880-2887, 2008
4. Penetration Pathways Induced by Low-Frequency Sonophoresis with Physical and Chemical Enhancers: Iron Oxide Nanoparticles versus Lanthanum Nitrates. Lee Sang Eun, Choi Ki Ju, Menon GK, Kim Hyun Jung, Choi Eung Ho, Ahn Sung Ku, Lee Seung Hun. J Invest Dermatol. 130(4):1063-72, 2010
5. Stimulation of epidermal calcium gradient loss increases the expression of hyaluronan and CD44 in mouse skin. Lee Sang Eun, Jun Jung Eun, Choi Eung Ho, Ahn Sung Ku, Lee Seung Hun. Clin Exp Dermatol. 2010; 35(6): 650-7