복진웅 / BOK, Jin Woong
조교수

Department / Institute / Center :
Department of Anatomy
Developmental Biology Laboratory

Contact Information

Phone +82-2-2228-1650 Email bokj@yuhs.ac Website www.yonseidev.org/bok/

Educational Background

Undergraduate Education B.S. Biology, Yonsei University, 1992 ,M.S. Biology, Yonsei University, 1994
Final Degree (University, Major) Ph.D. Neuroscience, University of Iowa, 2002
Overseas Training (Institute, Supervisor) National Institute on Deafness and other Communication Disorders(NIDCD), National Institutes of Health(NIH), Doris K. Wu, Ph.D. 2002-2008

Professional Societies and current positions

Association for Research in Otolaryngology, member
Society for Developmental Biology, member
대한해부학회, 회원
대한의생명과학회, 이사

Research Area(s)

Basic research, Translational research
Research Field Development, Plasticity, and regeneration of sensory cells and neurons of the inner ear
Elucidation of pathological mechanisms of genetically inherited hearing loss
Genetic profiling using microarray analysis in the inner ear
Diseases hearing impairments, balance disorders, genetic diseases
Possible Collaboration Elucidating pathological mechanisms of genetic diseases using animal models.
Elucidating molecular mechanisms governing vertebrate development

Research Methods

Analysis of genetically engineered mouse models - transgenics, knockouts, tissue and/or time-specific conditional knockouts
Chicken embryo manipulation - microsurgery, bead implantation
Isolation and culture of mouse primary spiral ganglion neurons
Confocal microscopy, immunohistochemistry
In situ hybridization - cryosection, whole mount
General cell and molecular biology techniques

Lab.

연구실사이트 바로가기
Location of Office 의대신관 143호
Location of Lab. 의대신관 139호
Contact person Name: 권현정 (조교) / Tel: 2228-1658 / E-mail: khj122@yuhs.ac

Major Published Articles and Books

1) Bok J*, Raft S, Kong KA, Koo SK, Dräger UC, and Wu DK* (2011) Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear. Proc Natl Acad Sci USA. 108(1): 161-166. (*corresponding authors)
2) Song MH, Choi SY, Wu L, Oh SK, Lee HK, Lee DJ, Shim DB, Choi JY, Kim UK, and Bok J (2011) Pou3f4 deficiency causes defects in otic fibrocytes and stria vascularis by different mechanisms. Biochem Biophys Res Comm. 404(1): 528-533.
3) Lee HK, Song MH, Kang M, Lee JT, Kong KA, Choi SJ, Lee KY, Venselaar H, Vriend G, Lee WS, Park HJ, Kwon TK, Bok J* and Kim UK* (2009) Clinical and molecular characterizations of novel POU3F4 mutations reveal that DFN3 is due to null function of POU3F4 protein. Physiological Genomics. 39: 195-201. (*corresponding authors)
4) Bok J, Dolson DK, Hill P, Ruther U, Epstein DJ and Wu DK (2007) Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development. 134(9): 1713-1722.
5) Bok J, Bronner-Fraser M and Wu DK (2005) Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear. Development. 132(9): 2115-2124.