이종은 / LEE, Jong Eun
교수

Department / Institute / Center :
Department of Anatomy, Yonsei University College of Medicine,
BK 21 Project for Medical Science

Contact Information

Phone +82-2-2228-1646 Email jelee@yuhs.ac Website

Educational Background

Undergraduate Education Bs., Biochemistry of Yonsei University, 1983
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 1993
Overseas Training (Institute, Supervisor) Stanford Univ., Medical School, Dept. of Anesthesia
Post Doc, 1996.-1998

Professional Societies and current positions

여성생명과학포럼, 부회장, 2014-현재
한국뇌신경과학회, 재무이사, 2013-현재
대한해부학회, 연구윤리위원장&해외교류위원, 2003-현재
대한해부학회, 총무이사, 2014-현재
Anatomy and Cell Biology (ACB), Executive Editor, 1985-현재

Research Area(s)

Basic research, Translational research, Drug trial
Research Field 1. The characteristics of functional stem cells expressing ADC gene and application
2. Therapeutic efficacy of ADC-NSCs against various CNS diseases
3. Neural differentiation mediated by arginine metabolome
4. Repair mechanisms in maintaining the blood brain barrier (BBB) integrity of endothelial cells after ischemic injured brain blood vessel with anti-oxidant therapy
5. The therapeutic mechanisms of post stroke dementia and alzheimer’s disease
Diseases Stroke, Spinal cord injury, dementia, ex vivo culture system
Possible Collaboration

Research Methods

1) Induction of ischemic preconditioning and focal ischemia
2) Complete transection spinal cord injury model
3) Cortical neural stem cell, neuron, astrocyte, primary culture, Ex vivo culture
4) siRNA, miRNA, lentivirus, retroviral gene transfer
5) Confocal microscopy, immunohistochemistry
6) FACS analysis, apoptosis assay, HPLC assay
7) Morphometric measurement of brain edema and infarct volume
8) Methylation specific polymerase chain reaction assay
9) Behavioral test: open-field test, surface right reflex test, rotarod test, Limb Placing test, BBB test, Passive avoidance test, Water Maze, Radial Maze, Y Maze 등
10) Paraffin emdedding section, freezing section

Lab.

연구실사이트 바로가기
Location of Office 의대신관 146호
Location of Lab. 의대신관 136,137호
Contact person Name: 김재환 / Tel: 2228-1659 / E-mail: JHKIM74@yuhs.ac

Major Published Articles and Books

1. Jae Hwan Kim, Yong Woo Lee, Kyung Ah Park, Won Taek Lee, Jong Eun Lee: Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia. J Cereb Blood Flow Metab May; 30(5): 943-949, 2010
2. Kiran Kumar Bokara, Kihyo Kwon, Yoon Mi Nho , Won Taek Lee, Kyung Ah Park, Jong Eun Lee: Retroviral expression of arginine decarboxylase attenuates oxidative burden in mouse cortical neuronal stem cells. Stem Cells Dev. 20(3): 527-537, 2011
3. Yu Mi Park1,2, Won Taek Lee1, Kiran Kumar Bokara1, Su Kyung Seo1,2, Seung Hwa Park3, Jae Hwan Kim, Kyung Ah Park1, Jong Eun Lee1,2,*: The mutifaceted effects of agmatine on functional recovery after spinal cord injury through modulation of BMP-2/4/7 expressions in neurons and glial cells. PLoS One 8(2): e53911, 2013
4. Juhyun Song, Bo Eun Hur, Kiran Kumar Bokara, Wonsuk Yang, Hyun Jin Cho, Kyung Ah Park, Won Taek Lee, Kyoung Min Lee, Jong Eun Lee: Agmatine improves cognitive dysfunction and prevents cell death in Streptozotocin-induced Alzheimer rat model. Yonsei Medical Journal 55(3): 689-699, 2014
5. Juhyun Song, So Mang Kang, Won Taek Lee, Kyung Ah Park, Kyoung Min Lee, Jong Eun Lee: The beneficial effect of melatonin in brain endothelial cells against oxygen-glucose deprivation followed by reperfusion (OGD/R) induced injury. Oxidative Medicine and Cellular Longevity 2014: 639531, 2014