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ÀÌÁ¾Àº / LEE, Jong Eun Department / Institute / Center : |
Phone | +82-2-2228-1646 | jelee@yuhs.ac | Website |
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Undergraduate Education | Bs., Biochemistry of Yonsei University, 1983 |
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Final Degree (University, Major) | Ph.D., Graduate School, Yonsei University, 1993 |
Overseas Training (Institute, Supervisor) | Stanford Univ., Medical School, Dept. of Anesthesia Post Doc, 1996.-1998 |
¿©¼º»ý¸í°úÇÐÆ÷·³, ºÎȸÀå, 2014-ÇöÀç Çѱ¹³ú½Å°æ°úÇÐȸ, À繫ÀÌ»ç, 2013-ÇöÀç ´ëÇÑÇØºÎÇÐȸ, ¿¬±¸À±¸®À§¿øÀå&ÇØ¿Ü±³·ùÀ§¿ø, 2003-ÇöÀç ´ëÇÑÇØºÎÇÐȸ, Ãѹ«ÀÌ»ç, 2014-ÇöÀç Anatomy and Cell Biology (ACB), Executive Editor, 1985-ÇöÀç |
Basic research, Translational research, Drug trial |
Research Field | 1. The characteristics of functional stem cells expressing ADC gene and application 2. Therapeutic efficacy of ADC-NSCs against various CNS diseases 3. Neural differentiation mediated by arginine metabolome 4. Repair mechanisms in maintaining the blood brain barrier (BBB) integrity of endothelial cells after ischemic injured brain blood vessel with anti-oxidant therapy 5. The therapeutic mechanisms of post stroke dementia and alzheimer¡¯s disease |
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Diseases | Stroke, Spinal cord injury, dementia, ex vivo culture system |
Possible Collaboration |
1) Induction of ischemic preconditioning and focal ischemia 2) Complete transection spinal cord injury model 3) Cortical neural stem cell, neuron, astrocyte, primary culture, Ex vivo culture 4) siRNA, miRNA, lentivirus, retroviral gene transfer 5) Confocal microscopy, immunohistochemistry 6) FACS analysis, apoptosis assay, HPLC assay 7) Morphometric measurement of brain edema and infarct volume 8) Methylation specific polymerase chain reaction assay 9) Behavioral test: open-field test, surface right reflex test, rotarod test, Limb Placing test, BBB test, Passive avoidance test, Water Maze, Radial Maze, Y Maze µî 10) Paraffin emdedding section, freezing section |
Location of Office | ÀÇ´ë½Å°ü 146È£ |
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Location of Lab. | ÀÇ´ë½Å°ü 136,137È£ |
Contact person | Name: ±èÀçȯ / Tel: 2228-1659 / E-mail: JHKIM74@yuhs.ac |
1. Jae Hwan Kim, Yong Woo Lee, Kyung Ah Park, Won Taek Lee, Jong Eun Lee: Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia. J Cereb Blood Flow Metab May; 30(5): 943-949, 2010 2. Kiran Kumar Bokara, Kihyo Kwon, Yoon Mi Nho , Won Taek Lee, Kyung Ah Park, Jong Eun Lee: Retroviral expression of arginine decarboxylase attenuates oxidative burden in mouse cortical neuronal stem cells. Stem Cells Dev. 20(3): 527-537, 2011 3. Yu Mi Park1,2, Won Taek Lee1, Kiran Kumar Bokara1, Su Kyung Seo1,2, Seung Hwa Park3, Jae Hwan Kim, Kyung Ah Park1, Jong Eun Lee1,2,*: The mutifaceted effects of agmatine on functional recovery after spinal cord injury through modulation of BMP-2/4/7 expressions in neurons and glial cells. PLoS One 8(2): e53911, 2013 4. Juhyun Song, Bo Eun Hur, Kiran Kumar Bokara, Wonsuk Yang, Hyun Jin Cho, Kyung Ah Park, Won Taek Lee, Kyoung Min Lee, Jong Eun Lee: Agmatine improves cognitive dysfunction and prevents cell death in Streptozotocin-induced Alzheimer rat model. Yonsei Medical Journal 55(3): 689-699, 2014 5. Juhyun Song, So Mang Kang, Won Taek Lee, Kyung Ah Park, Kyoung Min Lee, Jong Eun Lee: The beneficial effect of melatonin in brain endothelial cells against oxygen-glucose deprivation followed by reperfusion (OGD/R) induced injury. Oxidative Medicine and Cellular Longevity 2014: 639531, 2014 |