김형표 / KIM, Hyoung-Pyo
부교수

Department / Institute / Center :
Environmental Medical Biology
환경의생물학교실
열대의학연구소

Contact Information

Phone +82-2-2228-1842 Email kimhp@yuhs.ac Website

Educational Background

Undergraduate Education BS, Seoul National University, 1990
Final Degree (University, Major) Ph.D., Seoul National University, 1998
Overseas Training (Institute, Supervisor) National Institutes of Health,
Warren J. Leonard, MD, 1998-2008

Professional Societies and current positions

한국유전체학회, 학술운영위원, 2010-현재
생화학분자생물학회, 소식지 편집위원, 2009, 2011
Asian Epigenomics Meeting, 운영위원, 2010
American association of Immunologists, 회원, 2004 –현재
대한기생충학회, 회원, 2008-현재

Research Area(s)

Basic research, Translational research
Research Field 1. Chromatin-based regulatory mechanism governing cytokine gene transcription and helper T cell differentiation
2. Identification of novel epigenetic biomarkers for human cancer
3. Development of new therapeutic strategies targeting cancer stem cells
Diseases Autoimmune disease, Allergy, Inflammation, Cancer
Possible Collaboration 1. 유전자 전사 및 조절
2. Genome-wide mapping of DNA methylation or histone modification
3. T cell differentiation과 관련된 세포 분자생물학적 연구
4. BAC transgenic mouse 모델을 이용한 생체추적시스템 개발
5. Knockout mouse의 면역학적 특성 분석

Research Methods

1. DNA methylation: MIRA-seq, Bisulfite sequencing, COBRA
2. DNA-protein interaction: ChIP-seq, Chromatin immunoprecipitation, EMSA
3. Chromatin modification: Chromatin conformation capture (3C) assay, Restriction Enzyme Accessibility assay, DNase I hypersensitivity assay
4. Transcriptional regulation: Real-time PCR, luciferase assay
5. Mouse model: BAC Recombineering, BAC transgenic mice, Knock-out mice, Knock-in mice
6. T cell differentiation: isolation and in vitro differentiation of CD4 T cells
7. FACS analysis: Proliferation assay, Apoptosis assay, Side population assay, Intracellular staining analysis
8. Overexpression or knockdown of target gene using lentivirus

Lab.

연구실사이트 바로가기
Location of Office 의대 신관 251호
Location of Lab. 의대 신관 251호
Contact person Name: 박근희 / Tel: 2228-1856 / E-mail: merde2000@naver.com

Major Published Articles and Books

1. Jin W., Lee J., Kim M. S., Son B. H., Cho Y. K., and Kim H. P., 2011. DNA methylation-dependent regulation of TrkA, TrkB, and TrkC genes in human hepatocellular carcinoma. Biochemical and Biophysical Research Communications. 406, 89-95
2. Kim H. P. and W. J. Leonard, 2007. CREB/ATF-dependent T-cell Receptor-induced Foxp3 Gene Expression: a Role for DNA Methylation. J. Exp. Med. 204, 1543-1551
3. Kim H. P., L. L. Korn, and W. J. Leonard, 2005. Calcium dependent activation of IL-21 gene expression in T cells. J. Biol. Chem. 280, 25291-25297.
4. Kim, H. P., W. J. Leonard, 2002. The Basis for TCR-mediated IL-2 receptor alpha gene regulation: Role of Widely separated regulatory elements. EMBO J., 21, 3051-3059
5. Kim, H. P., J. K. Kelly, and W. J. Leonard, 2001. The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: Importance of two widely separated IL-2 response elements. Immunity, 15, 159-172