신전수 / SHIN, Jeon-Soo
교수

Department / Institute / Center :
Microbiology and Immunology (미생물학교실)
Institute of Immunology and Immunological Diseases (면역질환연구소)
Severance Biomedical Science Institute (의생명과학부)

Contact Information

Phone +82-2-2228-1816 Email jsshin6203@yuhs.ac Website ://www.yuhs-microbiology.org/

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1986
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 1992
Overseas Training (Institute, Supervisor) University of Rochester

Professional Societies and current positions

연세의대 (미생물학교실 주임교수, 의생명과학부 부장)
대한면역학회 (이사, Immune Network 편집위원)
대한미생물학회 (감사 및 평의원, J Bacteriol Virol 편집위원)
American Association of Immunologists (회원)
American Society of Microbiology (회원)

Research Area(s)

Basic research, Translational research, Other(nanomedical)
Research Field Innate immunity, Infection and immunity, Inflammation and disease pathogenesis, Sepsis, Neuroimmunology, Endogenous molecule (DAMP, HMGB1) and alarmin role
Ab chemistry, serodiagnostics
Nanomedical application, Tumor immunology
Diseases Inflammation and diseases, Sepsis, Autoimmunity, Tumor immunology, Neuroimmunology, Seroimmunological diagnostics.
Possible Collaboration Innate immunity, sepsis and immunological diseases, Inflammatory signal pathway
Monoclonal and polyclonal production and application, Tumor immunology
Immunological methods and serodiagnotic-related works, Models of Nanomedical approach, Angiogenesis study

Research Methods

Immunological methods: cell proliferation test, cultures, animal study, etc
Monoclonal and polyclonal Ab technology, Ab purification, and Ab chemistry
Immunological bioassays: ELISA, bioassays, Surface Plasmon Resonance, IFA, etc
Tumor immunology, HUVEC and angiogenesis study
Microbe culture and handling: bacteria, virus, etc.
Phage display
Image: confocal microscopy, IFA, etc
Molecular biology techniques: protein, DNA, RNA

Lab.

연구실사이트 바로가기
Location of Office 의대신관 2층 246호
Location of Lab. 의대신관 2층 246호
Contact person Name: 곽만섭/최영미 / Tel: 2228-1827/1810 / E-mail: jsshin6203@yuhs.ac

Major Published Articles and Books

A. Innate immunity, inflammation and diseases
HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism. J Immunol 2009;182:5800-5809; HMGB1 binding to lipopolysaccharide (LPS) facilitates transfer of LPS to CD14 and enhances LPS-mediated TNF- production in human monocytes. J Immunol 2008;180:5067-5074; Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it towards secretion. J Immunol 2006;177:7889-97.
B. Vaccine, Ab chemistry, infection, and serodiagnostics.
Anti-idiotypic antibody as a potential candidate vaccine for Neisseria meningitidis serogroup B Infect Immun 2005;73:6399-405.
C. Nanomedical field application.
Artificial control of nano-cell signaling and growth via magnetic nanoparticles. Angew Chem Int Ed 2010;49:5698-5702; Dual mode nanoparticle probes for high performance magnetic resonance and fluorescence imaging of neuroblastoma. Angew Chem Int Edit 2006;45:8160-8162.