권혁문 / KWON, Hyuck Moon
교수

Department / Institute / Center :
Department of Cardiology and heart Center Gangnam Severance Hospital

Contact Information

Phone +82-2-2019-3303, 3330 Email : kwonhm@yuhs.ac Website

Educational Background

Undergraduate Education M.D. Yonsei University, Seoul, Korea, 1978-1984
Final Degree (University, Major) Degree of Master Yonsei University, Seoul, Korea, 1986-1988
Overseas Training (Institute, Supervisor) 1.Department of Internal Medicine and Cardiovasular Diseases Mayo Clinic and Mayo Foundation

2.Professor, Department of Internal Medicine and Cardiovasular Diseases, Yonsei University College of Medicine, Mar., 2005-present

3.Professor and Director, Department of Cardiology and Heart center, Sept., 2006-present

Professional Societies and current positions

순환기의공학회 학술이사. 부회장
대한심장 학회 평의원 /이사
대한 혈전.지혈 학회 이사
사단 법인심혈관 연구원 부이사장
연세대학교 노화과학 연구소 상임연구
연세대학교 의과대학 심혈관 연구소 상임 연구원 /운영위원

Research Area(s)

Translational research, Clinical research
Research Field Idenfication of the pathbiological role of microparticle-tissue factor and development of Biomarker in the atherosclerotic vascular disease.
Potential role of HMG CoA reductase inhibitor on oxidative stress induced by advanced glycation endproducts in vascular smooth
Diseases muscle cells of diabetic vasculopathy.
Pathobiological role of advanced glycation endproducts via mitogen-activated protein kinase dependent pathway in the diabetic vasculopathy
Possible Collaboration pathbiological role of microparticle-tissue factor and development of Biomarker in the atherosclerotic vascular disease.
Microparticles in the cardiovascular disease
Genetic engineered stem cells in cardiac myogenesis and angiogenesis

Research Methods

Specimens with atherosclerotic plaque
confocal microscopy
Cell culture with lentivirus
Immunohistochemistry
FACS

Lab.

연구실사이트 바로가기
Location of Office 강남세브란스병원 임상연구센터
Location of Lab. 강남세브란스병원 임상연구센터
Contact person Name: 권혁문 / Tel: : 82-2-2019-3330~4 / E-mail: kwonhm@yuhs.ac

Major Published Articles and Books

9: Yoon SJ, Yoon YW, Lee BK, Kwon HM, Hwang KC, Kim M, Chang W, Hong BK, Lee YH,
Park SJ, Min PK, Rim SJ. Potential role of HMG CoA reductase inhibitor on
oxidative stress induced by advanced glycation endproducts in vascular smooth
muscle cells of diabetic vasculopathy. Exp Mol Med. 2009 Nov 30;41(11):802-11.
PubMed PMID: 19641377; PubMed Central PMCID: PMC2788734.

24: Yoon YW, Kwon HM, Hwang KC, Choi EY, Hong BK, Kim D, Kim HS, Cho SH, Song KS,
Sangiorgi G. Upstream regulation of matrix metalloproteinase by EMMPRIN;
extracellular matrix metalloproteinase inducer in advanced atherosclerotic
plaque. Atherosclerosis. 2005 May;180(1):37-44. Epub 2005 Jan 19. PubMed PMID:
15823273.

40: Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE, Jang Y, Cho SY, Kim HS.
Potential role of leptin in angiogenesis: leptin induces endothelial cell
proliferation and expression of matrix metalloproteinases in vivo and in vitro.
Exp Mol Med. 2001 Jun 30;33(2):95-102. PubMed PMID: 11460888.

53: Kwon HM, Sangiorgi G, Ritman EL, Lerman A, McKenna C, Virmani R, Edwards WD,
Holmes DR, Schwartz RS. Adventitial vasa vasorum in balloon-injured coronary
arteries: visualization and quantitation by a microscopic three-dimensional
computed tomography technique. J Am Coll Cardiol. 1998 Dec;32(7):2072-9. PubMed
PMID: 9857895.

55: Kwon HM, Sangiorgi G, Spagnoli LG, Miyauchi K, Holmes DR Jr, Schwartz RS,
Lerman A. Experimental hypercholesterolemia induces ultrastructural changes in
the internal elastic lamina of porcine coronary arteries. Atherosclerosis. 1998
Aug;139(2):283-9. PubMed PMID: 9712334.

58: Kwon HM, Sangiorgi G, Ritman EL, McKenna C, Holmes DR Jr, Schwartz RS, Lerman
A. Enhanced coronary vasa vasorum neovascularization in experimental
hypercholesterolemia. J Clin Invest. 1998 Apr 15;101(8):1551-6. PubMed PMID:
9541483; PubMed Central PMCID: PMC508734.