김명희 / KIM, Myoung Hee
교수

Department / Institute / Center :
Department of Anatomy
Embryology Laboratory
해부학교실 발생학실험실

Contact Information

Phone +82-2-2228-1647 Email mhkim1@yuhs.ac Website http://www.yonseidev.org/kim/index.html

Educational Background

Undergraduate Education BS. Department of Biology, Yonsei University, South Korea, 1980
Final Degree (University, Major) PhD. Department of Biology, University of California Los Angeles(UCLA) USA, 1985
Overseas Training (Institute, Supervisor) Post-doc. Max-Planck-Institute of Biophysical chemistry, Goettingen, Germany, Advisor - Peter Gruss, PhD, 1990-1992

Professional Societies and current positions

해부학교실 주임교수, 2014-현재
한국여성과학기술단체총연합회 (여과총), 이사, 2010-현재
한국 분자세포생물학회, 대의원, 2010-현재
Society for Developmental Biology, 회원, 2003-현재
New York Academy of Sciences, 회원, 2006-현재

Research Area(s)

Basic research
Research Field Spatiotemporal activation of Hox genes during mouse embryogenesis
Elucidating epigenetic mechanisms for Hox gene expression
The effect of maternal stress on embryonic and placental development
Functional role of HOX genes in breast cancer tumorigenesis and progression
Diseases homeotic mutation, congenital anomaly, breast cancer
Possible Collaboration The pathophysiology of Hox genes and their role in cancer
Hox genes and congenital abnormalities

Research Methods

Manipulation of mouse embryos
Isolation and culture of primary mouse embryonic fibroblast
Animal cell culture
RNA and Protein analysis (RT-PCR, In situ hybridization, Western Blotting, IP, IHC)
Chromatin immunoprecipitation (ChIP)-PCR or ChIP-Seq analysis
Chromosome conformation capture (3C) & 4C
In vitro tumor cell invasion and migration assay
Soft agar assay for tumor colony-forming cells / 3D-culture

Lab.

연구실사이트 바로가기
Location of Office 의대신관 145호
Location of Lab. 의대신관 140호
Contact person Name: 이지연 / Tel: 2228-1657 / E-mail: jylee517@yuhs.ac

Major Published Articles and Books

1. Akt1 mediates the posterior Hoxc gene expression through epigenetic modifications in mouse embryonic fibroblasts. Biochim Biophys Acta. (2014) 1839;793-799.
2. Analysis of HOX gene expression patterns in human breast cancer. Mol Biotechnol (2014) 56:64-71.
3. Akt1 as a putative regulator of Hox genes. Gene (2013) 513-287-291.
4. Hoxc gene collinear expression and epigenetic modifications established during embryogenesis are maintained until after birth. Int J Biol Sci (2013) 9:960-965.
5. Prenatal administration of dexamethasone during early pregnancy negatively affects placental development and function in mice. J Anim Sci (2012) 90:4846-4856.