김규언 / Kim, Kyu-Earn
교수

Department / Institute / Center :
Pediatrics
Institute of Allergy

Contact Information

Phone 82-2-2019-3353 Email kekim@yuhs.ac Website

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1977
Final Degree (University, Major) Ph.D., Graduate School, Catholic University, 1991
Overseas Training (Institute, Supervisor) Minnesota Medical School, Allergology
1991-1993

Professional Societies and current positions

(사)대한천식알레르기협회, 감사, 2009-현재
건강보험심사평가원 진료심사평가위원회, 비상근심사위원, 2009-현재
보건복지부 어린이건강정책 특별위원회, 위원, 2007-현재
연세의대 부속 알레르기 연구소, 소장, 2007-현재
대한 소아알레르기 호흡기학회, 이사장, 2005-2007

Research Area(s)

Basic research, Clinical research
Research Field Assessment of food allergenicity and GMO safety
Investigation of etiologic factors and development of treatment for allergic diseases
Genetic and epigenetic regulation of specific genes to allergic diseases
Diseases allergic disease (food allergy, asthma, atopic dermatitis), innate immunity, airway remodeling and inflammation, epigenetics, cellular and molecular immunology
Possible Collaboration 1. 식품알레르기와 관련된 혈청은행 확보 및 확충
2. 섭취식품에 대한 안전성 및 유전자 변형식품의 알레르기 유발 가능성 평가기준 마련
3. 다양한 동물모델을 통한 알레르기질환 주요 병인기전연구 및 치료법 개발
4. 환자들의 DNA 염기서열 및 유전정보를 근거로 한 유전학 및 후생유전학 연구를 통해 특정알레르기질환에 대한 inter-individual variability 정보구축

Research Methods

Allergen extraction and purification, Serologic and molecular analysis of food allergen
Lung injury, asthma or atopic dermatitis animal model experiment
apoptosis assay, FACS analysis
promoter assay, EMSA, RT-PCR
Chromatin immunoprecipitation assay, HDAC and HAT activity assay

Lab.

연구실사이트 바로가기
Location of Office 강남 세브란스 별관 소아청소년 교수실
Location of Lab. 임상의학 연구센터 321호 (알레르기연구소)
Contact person Name: 이경은,홍정연,김미나 / Tel: 2228-2809 / E-mail: pedal@yuhs.ac

Major Published Articles and Books

- Wild Rice, Hypoallergenic Rice, and GMO Rice-Immuologic Comparison. Yum HY, Lee KE, Kim KE. Pediatr Allergy Respir Dis. 2005;15:117-125
-Basement membrane thickening and clinical features of children with asthma.
Allergy. Kim ES, Kim SH, Kim KE. 2007 ;62:635-40
- Regulation of German cockroach extract-induced interleukin-8 expression in human airway epithelial cells. Lee KE, Kim JW, Kim KE. Clin Exp Allergy. 2007 ;37:1364-73.
- Chitinase activates protease-activated receptor-2 in human airway epithelial cells. Am J Respir Cell Mol Biol. 2008;39:530-5.
- Genetic Variation in the Promoter Region of Chitinase 3-Like 1 Is Associated with Atopy. Sohn MH, Lee JH, Kim KE. Am J Respir Crit Care Med. 2009;179:449-56.
-The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury. MH Shon, MJ Kang, Jack AE. Am J respire Crit Care Med. 2010;182:918-28.