박민수 / Park, Min Soo
부교수

Department / Institute / Center :
Pediatrics (Neonatology); Clinical Pharmacology / Clinical Trials Center
소아과학교실 신생아과; 임상약리학과 / 임상시험센터

Contact Information

Phone +82-2228-0400; +82-10-8740-1611 Email minspark@yuhs.ac Website

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1986
Final Degree (University, Major) Ph.D., Graduate School, Ajou University, 2011
Overseas Training (Institute, Supervisor) University of Aberdeen, UK, Dept. of Medicine & Therapeutics, Div. of Clinical Pharmacology; Prof. J. C. Petrie, MD, PhD 1994-1995
Columbus Children’s Research Institute, OH, USA; Prof. Charles V. Smith, PhD 2001-2003

Professional Societies and current positions

대한소아과학회
대한신생아학회, 학술위원장(2008-2010); 임상연구 TF 위원장(2011-현재)
대한임상약리학회, 대외협력이사(2012-현재)
American Society for Clinical Pharmacology and Therapeutics, International Task Force Member (2011-현재)

Research Area(s)

Translational research, Clinical research, Drug trial
Research Field • Mechanisms involved in lung development and alveolarization
• Pathophysiology and treatment of bronchopulmonary dysplasia in neonates
• Clinical pharmacokinetic – pharmacodynamic – pharmacogenetic/-genomic studies of new drugs in healthy volunteers and patient populations (First-in-man studies; phase 1-2a studies)
• Drug metabolism and drug interaction studies
Diseases • Lung diseases (respiratory distress syndrome, bronchopulmonary dysplasia) in preterm infants
• Oxygen toxicity
• Early phases of new drug development
Possible Collaboration • Clinical pharmacokinetic – pharmacodynamic – pharmacogenetic/-genomic studies of new drugs in various therapeutic areas
• Animal (newborn mice) model for hyperoxic lung injury
• Development of new drugs and therapeutic modalities for chronic lung diseases in preterm infants

Research Methods

• Animal (newborn mice) model for hyperoxic lung injury
• Lung morphometry
• Quantitative immunohistochemistry
• Drug metabolism and pharmacokinetic studies in human (single ascending and multiple ascending doses)
• Drug concentration analysis and proteomic analysis using LC/MS/MS and HPLC

Lab.

연구실사이트 바로가기
Location of Office Clinical Trials Center, 2 Floor, Jejung Gwan
Location of Lab. Clinical Trials Center, 2 Floor, Jejung Gwan
Contact person Name: Eun-Sil Oh, MD (Clinical Assistant Professor) / Tel: 2228-0456 / E-mail: esoh@yuhs.ac

Major Published Articles and Books

• Park MS, Sohn MH, Kim K-E, Park MS, Namgung R, Lee C. 5-Lipoxygenase-Activating Protein (FLAP) Inhibitor MK-0591 Prevents Aberrant Alveolarization in Newborn Mice Exposed to 85% Oxygen in a Dose- and Time-Dependent Manner. Lung 18:943-50 (2011)
• Park MS, Rieger-Fackeldey E, Schanbacher BL, Cook AC, Bauer JA, Rogers LK, Hansen TN, Welty SE, Smith CV. Altered expressions of fibroblast growth factor receptors and alveolarization in neonatal mice exposed to 85% oxygen. Pediatr Res 62(6):652-657 (2007)
• Lee SM, Chung JY, Lee YM, Park MS, Namgung R, Park KI, Lee C. Effects of cytochrome P450 (CYP)2C19 polymorphisms on pharmacokinetics of phenobarbital in neonates and infants with seizures. Arch Dis Child 2012 doi:10.1136