전지혜 / Jun Ji Hae
연구조교수

Department / Institute / Center :
의생명과학부
마취통증의학 연구실

Contact Information

Phone +82-2-2228-2410 Email ilovepodo@yuhs.ac Website

Educational Background

Undergraduate Education B.D. clinical pathology, yonsei university 2001
Final Degree (University, Major) PhD Graduate School, Seoul national University, 2008
Overseas Training (Institute, Supervisor)

Professional Societies and current positions

Research Area(s)

Basic research, Translational research, Clinical research, Drug trial
Research Field Role of GATA-4 in cardiovascular diease
Identification of a new drug target in Heart and kidney diseases
Diseases Ischemia-reperfusion, disease, cancer, hyperglycemia, signaling pathway, ROS
Possible Collaboration 후보약물의 핵심 단백질 조절 기전을 통한 역할 규명.
Cloning 등 분자생물학을 포함한 모든 세포생물학적 연구.

Research Methods

Cloning, 3D culture,
Mouse bone marrow cell culture,
Primary culture of calvarial osteoblasts and cardiomyocytes in rat or mouse.
siRNA, RT-PCR, Immunohistochemistry, Western, Immunoprecipitation, GST pull-down,
ubiquitination analysis, ALP staining, TRAP, Von kossa,
Zymography,
ROS generation analysis
CCK, MTT assay,
GSH/GSSG analysis,
ELISA

Lab.

연구실사이트 바로가기
Location of Office 의대본관 303호
Location of Lab. 임상의학센터 219호
Contact person Name: 신은정 / Tel: 2228-2801 / E-mail: 1109sej@naver.com

Major Published Articles and Books

1) Erythropoietin-activated ERK/MAP kinase enhances GATA-4 acetylation via phosphorylation of serine 261 of GATA-4. J Cell Physiol. 2013 Jan;228(1):190-7.
2) Propofol attenuates renal ischemia-reperfusion injury aggravated by hyperglycemia. J Surg Res. 2013 Mar 6. doi:pii: S0022-4804(13)00102-9.
3) Erythropoietin Prevents Hypoxia-Induced GATA-4 Ubiquitination via Phosphorylation of Serine 105 of GATA-4. Biol Pharm Bull. 2013; 36(7):1126-33.
4) Effects of propofol on the expression of matric metalloproteinases in rat cardiac fibroblasts after hypoxia and reoxygenation. Br J Anaesth. 2011 May;106(5):650-8.
5) BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity. J Biol Chem. 2010 Nov 19;285(47):36410-9