송시영 / SI YOUNG SONG
교수

Department / Institute / Center :
Department of Internal Medicine
Institute of Gastroenterology

Contact Information

Phone +82-2-2228-1957 Email sysong@yuhs.ac Website

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine,1983
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 1993
Overseas Training (Institute, Supervisor) Vanderbilt Cancer Center, Cell Biology, USA ,Post Doc, 1996-1998

Professional Societies and current positions

Director, Office of Medical Science Research Affairs
Director, Industry-Academy Cooperation Foundation
Chairman, Department of Gastroenterology, Severance Hospital
Director, Pancreatobiliary Cancer Center
Director, Yonsei Institute of Gastroenterology
President, Korean Society of Gastrointestinal Cancer

Research Area(s)

Translational research, Clinical research, Medical devices
Research Field Identifying the role of gastrointestinal cancer stem cells and its application of new diagnosis and therapeutic targets
Identification of gastrointestinal cancer related genes and its application of therapeutic antibody development
Development of gastrointestinal capsule endoscope devices and molecular optic imaging devices
Next generation sequencing of human pancreatic/ biliary cancer
Diseases Gastrointestinal disease (polyp, cancer)
Possible Collaboration Application of cancer stem cell related genes to cancer diagnosis and therapeutics
Screening of cancer stem cell targeted small molecules
Establishment of human pancreatic cancer/normal cell line
Functional study of pancreatic cancer stem cell specific microRNA
Validation of gene/protein in interest in human sample (tissue, serum, plasma, DNA)
Development of gastrointestinal cancer diagnosis kit
Development of gastrointestinal cancer targeted therapeutic antibody
Development of capsule micro-endoscopic devices
Development of molecular optic imaging applicable to endoscope

Research Methods

Sphere cultivation, cell culture, primary culture
Isolation of cancer stem cell
Establishment of therapeutic resistant cell line
Real time PCR, RT-PCR, gene silencing
Western blot, IF, IHC, IP, FACS analysis
Transgenic mouse
microRNA related work
development of cancer stem cell specific aptamer
Human next generation sequencing

Lab.

연구실사이트 바로가기
Location of Office #316 main building, college of medicine
Location of Lab. #305 new building, college of medicine
Contact person Name: Soo Been Park / Tel: 82-2-2228-2684 / E-mail: ellie0813@yuhs.ac

Major Published Articles and Books

Jin Wen, Jeong Youp Park, Kyung Hwa Park, Hye Won Chung, Seungmin Bang, Seung Woo Park Si Young Song. Oct4 and Nanog Expression is associated with early stages of pancreatic carcinogenesis. Pancreas. 2010 July; 39(5): 622-626.
Sungpil Hong, Jing Wen, Seungmin Bang, Seungwoo Park, Si Young Song. CD44-pisitive cells are responsible for gemcitabine resistance in pancreatic cancer cells. International Journal of Cancer. 2009 Nov 15;125(10):2323-31.
Sun A Kim, Yangsoon Lee, Dawoon E. Jung, Kyung Hwa Park, Jeong Youp Park, Jingu Gang, Sun Bok Jeon, Eui Chul Park, Young-Gun Kim, Bogman Lee, Qing Liu, Wen Zeng, Subramanyam Yeramilli, Soojin Lee, Sang Seok Koh, Si Young Song. Pancreatic adenocarcinoma up-regulated factor(PAUF), a novel up-regulated secretory protein in pancreatic ductal adenocarcinoma. Cancer Science 100(5): 828-836, May 2009.
Ji Eun Lee, Jing Wen, Jeong Youp Park, Sun-A Kim, Eun Jig Lee, Si Young Song. Reversal of Diabetes in rats using GLP-1-expressing adult pancreatic duct-like precursor cells transformed from acinar to ductal cells. Stem cells and Development 2009 Sep; 18(7): 991-1002
Seungmin Bang, Si Young Song. The first clinical trial of “MiRo” capsule endoscope using novel transmission technology: electric-field propagation. Gastrointestinal Endoscopy 2009: 69(2); 253-259.