곽영란 / Kwak, Young-Lan
교수

Department / Institute / Center :
Department of Anesthesiology and Pain Medicine,
Anesthesia and Pain Research Institute.
마취통증의학교실,
마취통증의학연구소

Contact Information

Phone +82-2-2228-8513 Email ylkwak@yuhs.ac Website

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1989
Final Degree (University, Major) Ph.D., Graduate School, Soonchunhyang University, 2002
Overseas Training (Institute, Supervisor) Myoclonic, Anesthetic Research Institute, Dr. Perkins WJ

Professional Societies and current positions

대한심폐혈관마취, 운영위원, 2000-현재
American Society of Cardiothorasic & Vascular Anesthesia, 1996-현재
Yonsei Med J, Editor, 2013-현재

Research Area(s)

Basic research, Translational research, Clinical research, Drug trial
Research Field Role of GATA-4 in cardiovascular disease
Protection effect against ischemia-reperfusion injury in Heart and kidney.
Identification of a new drug target in Heart and kidney disease
Diseases Ischemia-reperfusion, disease, cancer, hyperglycemia, signaling pathway, ROS
Possible Collaboration 허혈-재관류 손상 시 조직의 보호 효과를 분자생물학적 방법을 통하여 증명.
후보약물의 핵심 단백질 조절 기전을 통한 역할 규명.
Cloning 등 분자생물학을 포함한 모든 세포생물학적 연구.

Research Methods

Rat primary cardiac myocytes isolation and culture
293T, HK-2, H9c2 cell culture and differentiation
siRNA, shRNA, lentivirus, adenoviral gene transfer
Confocal microscopy, immunohistochemistry, apoptosis assay
Western, immunoprecipitation, luciferase assay
microRNA technique, Cloning, Recombinant protein preparation
ubiquitination analysis, ALP staining, TRAP, Von kossa,
Zymography, ROS generation analysis, CCK, MTT assay, GSH/GSSG analysis, ELISA

Lab.

연구실사이트 바로가기
Location of Office 의대본관 303호
Location of Lab. 임상연구센터 322호
Contact person Name: 전지혜 / Tel: 2228-2810 / E-mail: ilovepodo@yuhs.ac

Major Published Articles and Books

1) Double-blinded, randomised controlled trial of N-acetylcysteine for prevention of acute kidney injury in high risk patients undergoing off-pump coronary artery bypass. Nephrology (Carlton). 2014 Nov 11.
2) Association of carotid arterial circumferential strain with left ventricular function and hemodynamic compromise during off-pump coronary artery bypass surgery.
Circ J. 2014;78(10):2422-30. Epub 2014 Aug 28.
3) Erythropoietin-activated ERK/MAP kinase enhances GATA-4 acetylation via phosphorylation of serine 261 of GATA-4. J Cell Physiol. 2013 Jan;228(1):190-7.
4) Effect of combined remote ischemic preconditioning and postconditioning on pulmonary function in valvular heart surgery. Chest. 2012 Aug;142(2):467-75.
5) Effect of single recombinant human erythropoietin injection on transfusion requirements in preoperatively anemic patients undergoing valvular heart surgery.
Anesthesiology. 2011 Nov;115(5):929-37.