이은직 / Lee Eun Jig
교수

Department / Institute / Center :
Internal Medicine(Endocrinology)
Institute of Endocrine Research
Yonsei University College of Medicine
유한-연세 융합연구소

Contact Information

Phone +82-2-2228-0872 Email ejlee423@yuhs.ac Website http://blog.iseverance.com/ejlee423

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1984
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 1994
Overseas Training (Institute, Supervisor) Endocrinology, Northwestern University Feinberg School of Medicine, Chicago, USA, 60611 (1995-2006)

Professional Societies and current positions

연세대학교 의과대학 교무부학장
연세의생명연구원 부원장
세브란스병원 연구중심병원 육성사업단장
세브란스병원 뇌하수체종양클리닉 팀장
대한내분비학회 연구, 학술, 윤리, 기획이사
대한신경내분비연구회 학술위원장

Research Area(s)

Basic research, Translational research, Clinical research, Drug trial
Research Field 1. Regeneration therapy of endocrine insufficiency (Hypopituitarism, Hypothyroidism, Diabetes)
2. Thyroid carcinoma, Pituitary tumor, Graves’ orbitopathy
3. Atherosclerosis, Vascular endocrinology
4. Gene therapy and vector development (Adeno-AAV hybrid vector)
Diseases Pituitary tumor, Graves’ orbitopathy, Hypopituitarism, Atherosclerosis, Thyroid disease
Possible Collaboration 갑상선암과 뇌하수체 종양의 proteomics/peptidomics/genomics를 이용한 표지마커 발굴 및 신약 타겟 발굴
Adeno-AAV hybrid vector를 이용한 유전자 치료 및 세포 치료
동맥경화증(혈관합병증) 및 대사증후군, 지방간의 병인 연구와 신약개발 연구
갑상선 기능항진증에 동반된 갑상선 안구병증의 병인 연구와 신약개발 연구

Research Methods

Isolation and culture of vascular smooth muscle cells from rat/mouse aorta
Isolation and culture of orbital fibroblasts from human orbital fat
3T3-L1 preadipocyte culture and differentiation
Adenoviral gene transfer, siRNA/plasmid DNA transfection
Confocal microscopy, immunohistochemistry
FACS analysis, Apoptosis assay
Chromatin immunoprecipitation, EMSA, Luciferase assay
Knock-out animal experiment
Rat carotid artery balloon injury
Rebombinant protein preparation
RT-PCR, Real-time PCR
Immunoblotting, Immunoprecipitation
ELISA

Lab.

연구실사이트 바로가기
Location of Office 연세대학교 의과대학 1층 교무부학장실
Location of Lab. 연세에비슨의생명연구센터(ABMRC) 414호
Contact person Name: 조윤희 / Tel: 2228-0872 / E-mail: wooriminji@gmail.com

Major Published Articles and Books

1) FoxO1 is negative regulator of FSHβ gene expression in basal and GnRH-stimulated conditions in female. Endocrinology 2014 Jun; 155(6):2277-86
2) Resveratrol prevents Streptozotocin-induced diabetes by inhibiting the apoptosis of pancreatic β-cell and the cleavage of poly (ADP-ribose) polymerase. Endocr J. 2012 59(2):103-109
3) Nonmuscle Myosin Heavy Chain and Histone H3 are Intracellular Binding Partners of Lithospermic Acid B and Mediate its Antiproliferative Effect on VSMCs.Curr Med Chem 2012; 19(11):1731-7.
4) Therapeutic Effects of Water Soluble Danshen Extracts on Atherosclerosis. Evid Based Complement Alternat Med. 2013
5) Cigarette smoke extract-inducedadipogenes is in Graves’ orbital fibroblasts is inhibited by quercetin via reduction in oxidative stress. J Endocrinol 2013 Jan 18;216(2):145-56
6) Inhibition of Akt/FOXO3a signaling by constitutively active FOXO3a suppresses growth o.f follicular thyroid cancer cell lines.Cancer Lett. 2012 Jan 1;314(1):34-40