박승우 / Park , Seung Woo
교수

Department / Institute / Center :
Internal Medicine, Division of Gastroenterology, Institute of Gastroenterology

Contact Information

Phone +82-2-2228-1964 Email swoopark@yuhs.ac Website

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1990
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 2000
Overseas Training (Institute, Supervisor) Johns Hopkins Medical Institution. Dept. Surgical Oncology
Steve D. Leach MD, PhD, 2004.1-2006.1

Professional Societies and current positions

대한소화기암학회 재무이사 2014. 3 – 현재
대한췌담도학회 중개연구회 위원장 2014. 3 – 현재
대한췌담도학회 학술위원 2014.3-현재

Research Area(s)

Basic research, Translational research, Clinical research, Drug trial
Research Field Zebrafish model of gastrointestinal cancer by transgenesis and knock-out
Patient derived xenograft for tailored medicine of pancreatic cancer
Identification of novel target of pancreatic cancer
Drug screening for novel anticancer drug
Therapeutic endoscopy
Diseases Pancreatobiliary cancer
Possible Collaboration Any kind of study using zebrafish model
Generation of knock-out and transgenic model
Functional validation of novel gene or drug in zebrafish

Research Methods

-Transgenesis: Cell-specific expression of gene, Inducible expression system
-Knock-out by TALEN & RGEN
-Cloning technology in E.coli
-Microinjection of DNA, RNA, & drug
-In situ hybridization (whole mount & section slide)
-Real-time RT-PCR, Western blot, Immunofluorescence, Immunhistochemistry
-Xenograft of cell line and tumor
-Imaging using confocal, optical & flurescent microscope
-Primary cell culture of human cancer (pancreatic and biliary cancer)

Lab.

연구실사이트 바로가기
Location of Office 의과대학 3층 내과학교실 307호
Location of Lab. 의과대학 신관 507호(소화기병연구소-제브라피쉬 연구실)
Contact person Name: 정인혜 / Tel: 02-2228-2724 / E-mail: iherb21@yuhs.ac

Major Published Articles and Books

1. A pilot study of S‑1‑based concurrent chemoradiotherapy in patients with biliary tract cancer. Hee Man Kim • Kyong Joo Lee • Jihye Cha •Moon Jae Chung • Seungmin Bang • Jinsil Seong •Si Young Song • Seung Woo Park. Cancer Chemother Pharmacol (2014) 74:861–865.
2. Efficacy of concurrent chemoradiotherapy with 5-fluorouracil or gemcitabine in locally advanced biliary tract cancer or gemcitabine in locally advanced biliary tract cancer. Seung Woo Yi • Dae Ryong Kang • Kyung Sik Kim • Mi Suk Park • Jinsil Seong •Jeong Youp Park • Seung Min Bang • Si Young Song • Jae Bock Chung • Seung Woo Park. Cancer Chemother Pharmacol (2014) 73:191–198.
3. Glioma is formed by active Akt1 alone and promoted by active Rac1 in transgenic zebrafish. In Hye Jung†, Ga Lam Leem†, Dawoon E. Jung, Min Hee Kim, Eun Young Kim, Se Hoon Kim, Hae-Chul Park, and Seung Woo Park. Neuro Oncol. 2013 Mar;15(3):290-304.
4. Indian Hedgehog b Function Is Required for the Specification of Oligodendrocyte Progenitor Cells in the Zebrafish CNS. Ah-Young Chung,1 Suhyun Kim,1 Eunmi Kim,1 Dohyun Kim,1 Inyoung Jeong,1 Young Ryun Cha,1 Young-ki Bae,2 Seung Woo Park,3 Jehee Lee,4 and Hae-Chul Park1. The Journal of Neuroscience, January 23, 2013 • 33(4):1728 –1733.
5. Safety evaluation of self-expanding metallic biliary stents eluting gemcitabine in a porcine model. Moon Jae Chung,* Hyunki Kim,† Kyung Sik Kim,‡ Sangsoo Park,§ Jae Bock Chung* and Seung Woo Park*. Journal of Gastroenterology and Hepatology 27 (2012) 261–267.
6. A magnetic switch for the control of cell death signalling in in vitro and in vivo systems. Mi Hyeon Cho,1, 5, Eun Jung Lee,1, 2, 5, Mina Son,2, 5, Jae-Hyun Lee,1, Dongwon Yoo,1, Ji-wook Kim,1, Seung Woo Park,3, Jeon-Soo Shin2, 4, & Jinwoo Cheon. Nature Materials 11, 1038-1043(2012)
7. Aberrant Hedgehog Ligands Induce Progressive Pancreatic Fibrosis by Paracrine Activation of Myofibroblasts and Ductular Cells in Transgenic Zebrafish. In Hye Jung, Dawoon E. Jung, Young Nyun Park, Si Young Song, Seung Woo Park. Plos