안용호 / Ahn, Yong-Ho
교수

Department / Institute / Center :
1. 생화학-분자생물학교실 (Dept. Biochemistry and Molecular Biology)
2. 유전과학연구소 (Institue of Genetic Science)
3. 만성대사성질환연구센터 (Center for Chronic Metabolic Disease Research)
4. BK 21 플러스 (Brain Korea 21 plus Project)

Contact Information

Phone +82-2-2228-0835 Email yha111@yuhs.ac Website http://biochemistry.yonsei.ac.kr

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1979
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 1984
Overseas Training (Institute, Supervisor) UMDNJ-RWJ Medical School, Sydney Pestka, MD, PhD, 1987-1989

Professional Societies and current positions

만성대사성질환연구센터, 소장, 2002-2006
연세대학교 의과대학, 교학부처장, 2004-2006
한국보건산업진흥원 연구사업지원본부, 본부장, 2006-2008
연세대학교 의과대학, 도서관장, 2009-2013
Open Obesity Journal, Editor, 2008-현재

Research Area(s)

Basic research
Research Field Mechanism and regulation of hepatic steatosis, diabetes, and obesity
The role of transcription factors in glucose/lipid metabolism
Metabolic control of gene regulation in insulin resistance
Diseases DM, obesity, hepatic steatosis, metabolic syndrome, NAFLD
Possible Collaboration 포도당 항상성을 조절하는 메커니즘 및 신약개발
당뇨 및 비만의 조기진단을 위한 표지마커 발굴
지방세포 분화를 조절하는 새로운 기전 발굴

Research Methods

Mouse primary hepatocyte isolation and culture
3T3-L1 preadipocyte culture and differentiation
siRNA, shRNA, lentivirus, adenoviral gene transfer
Confocal microscopy, immunohistochemistry
Chromatin immunoprecipitation, EMSA, luciferase assay
Knock-out animal experiment
Recombinant protein preparation
Western blot, Real-time PCR, gene cloning
Obesity model mice (diet-induced, ob/ob, db,db)

Lab.

연구실사이트 바로가기
Location of Office 에비슨의생명연구센터 403호
Location of Lab. 에비슨의생명연구센터 418호
Contact person Name: 박주만 / Tel: 2228-0868 / E-mail: jjumans@yuhs.ac

Major Published Articles and Books

1) Txnip contributes to impaired glucose tolerance by upregulating the expression of genes involved in hepatic gluconeogenesis in mice. Jo SH, Kim MY, Park JM, Kim TH, Ahn YH. Diabetologia. 2013 Dec;56(12):2723-32

2) Adenovirus-mediated overexpression of Tcfe3 ameliorates hyperglycaemia in a mouse model of diabetes by upregulating glucokinase in the liver. Kim MY, Jo SH, Park JM, Kim TH, Im SS, Ahn YH. Diabetologia. 2013 Mar;56(3):635-43.


3) Glucose-stimulated upregulation of GLUT2 gene is mediated by sterol response element-binding protein-1c in the hepatocytes. Seung-Soon Im, Seung-Youn Kang, So-Youn Kim, Ha-Il Kim, Jae-Woo Kim, Kyung-Sup Kim, Yong-Ho Ahn. Diabetes. 2005 Jun;54(6):1684-91.

4) Liver glucokinase can be activated by peroxisome proliferator-activated receptor-gamma. So-Youn Kim, Ha-Il Kim, Sang-Kyu Park, Seung-Soon Im, Tianzhu Li, Hyae Gyeong Cheon, Yong-Ho Ahn. Diabetes. 2004 Feb;53 Suppl 1:S66-70.

5) Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells. Ha-il Kim, Ji-Young Cha, So-Youn Kim, Jae-woo Kim, Kyung Jin Roh, Je-Kyung Seong, Nam Taek Lee, Kang-Yell Choi, Kyung-Sup Kim, Yong-ho Ahn. Diabetes. 2002 Mar;51(3):676-85.