이용찬 / Lee, Yong-chan
교수

Department / Institute / Center :
Division of Gastroenterology
Department of Internal Medicine
Yonsei University College of Medicine

Contact Information

Phone +82-2-2228-1960 Email LEEYC@yuhs.ac Website http://blog.iseverance.com/leeyc

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1987
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 1998
Overseas Training (Institute, Supervisor) NYU School of Medicine, Dept. Medicine and Microbiology,
Martin J. Blaser, MD, PhD, 2000.8-2002.9

Professional Societies and current positions

Director, Esophageal Cancer Special Clinic, Severance Hospital, Yonsei University Health System, 2009.3-present
Director, Severance Hospital Endoscopy Center, 2013.3-present
Director, Ethics and Quality Control Committee, The Korean Society of Gastrointestinal Endoscopy, 2011.12-2013.12
Deputy editor, Gut and Liver, 2010.12-present
Associate editor, Journal of Gastroenterology and Hepatology (indexed in SCI), 2012.3-present

Research Area(s)

Basic research, Translational research, Clinical research
Research Field Role of Helicobacter pylori in gastric cancer
Application of miRNA in gastric cancer
Epigenetic regulation in gastric cancer cells
Identification of a new drug target in gastric diseases
Diseases Helicobacter pylori infection, Gastric ulcer, Gastritis, Gastric cancer, Esophageal cancer, Bacterial genomics, Cellular immunology
Possible Collaboration 위암에서 SIRT3/HIF1α 신호연관에 따른 대사 재프로그래밍 조절기전 연구
위암줄기세포의 상피중간엽 이행(Epithelial Mesenchymal Transition, EMT)특성과microRNA 네트워크의 후성유전학적 조절기전 연구

Research Methods

Bacteria, cell culture, and co-culture with H. pylori
Immunoblot analysis
Quantitative real-time RT-PCR
Invasion and migration assay
GSK-3βkinase assay
Reporter gene assay
siRNA, shRNA, lentivirus, adenoviral gene transfer
Immunofluorescence study
Clinical gastric tissue samples and immunohistochemistry
FACS analysis, apoptosis assay
Chromatin immunoprecipitation
Luciferase assay
microRNA technique

Lab.

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Location of Office 의대본관 3층 340호
Location of Lab. 의대신관 3층 305호
Contact person Name: 이도연 / Tel: 2228-2696 / E-mail: DOYEON2@yuhs.ac

Major Published Articles and Books

1) Helicobacter pylori CagA promotes Snail-mediated epithelial-mesenchymal transition by reducing GSK-3 activity. Lee DG1, Kim HS2, Lee YS3, Kim S3, Cha SY4, Ota I5, Kim NH4, Cha YH4, Yang DH4, Lee Y4, Park GJ6, Yook JI4, Lee YC3. Nat Commun. 2014 Jul 23; 5:4423.
2) Helicobacter pylori Induces Cell Migration and Invasion Through Casein Kinase 2 in Gastric Epithelial Cells. Lee YS1, Lee DY, Yu DY, Kim S, Lee YC. Helicobacter. 2014 Jul 23.
3) Genistein attenuates cancer stem cell characteristics in gastric cancer through the downregulation of Gli1. Yu D1, Shin HS2, Lee YS1, Lee D1, Kim S1, Lee YC1. Oncol Rep. 2014 Feb; 31(2):673-8.
4) Change in gene expression profiles of secreted frizzled-related proteins (SFRPs) by sodium butyrate in gastric cancers: induction of promoter demethylation and histone modification causing inhibition of Wnt signaling. Shin H1, Kim JH, Lee YS, Lee YC. Int J Oncol. 2012 May; 40(5):1533-42.
5) CagA phosphorylation-dependent MMP-9 expression in gastric epithelial cells. Nam YH1, Ryu E, Lee D, Shim HJ, Lee YC, Lee ST. Helicobacter. 2011 Aug; 16(4):276-83.