차봉수 / CHA, Bong-Soo
교수

Department / Institute / Center :
Internal Medicine (Endocrinology)
Institute of Endocrine Research
내분비연구소
당뇨병센터

Contact Information

Phone +82-2-2228-1962 Email bscha@yuhs.ac Website

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1988
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 1998
Overseas Training (Institute, Supervisor) UC San Diego, VA Hospital, Research Center,
Robert R. Henry, MD, PhD, 1998.2-2000.2

Professional Societies and current positions

대한 당뇨병학회, (전)총무이사, (전)홍보이사, (현)재무이사
대한 당뇨병 연구재단 이사, 2006-현재
연세의대 총동창회 (원내)총무이사, 2007-현재
당뇨병센터 소장, 2009-현재
세브란스병원 운영위원, 2007-현재

Research Area(s)

Translational research, Clinical research, Drug trial
Research Field Pathogenesis of diabetes esp. in insulin resistance
Role of PPARγ agonist
Dysregulation of lipid and cholesterol in diabetes and obesity
Metabolic effect of exercise
Identification of a new drug target in dementia with diabetes
Diseases Diabetes, Obesity, Insulin resistance, NAFLD, Exercise, dyslipidemia
Possible Collaboration 에너지대사 장애의 병인과 치료법 개발
인슐린 저항성의 기전과 치료 방법 연구
당뇨병과 관련한 질병의 기전과 치료법(예를 들면 치매, 암)
간지방증의 기전 연구, 비만세포의 병리 기전 연구

Research Methods

Mouse and rat experiment: esp. obese or HFD-model
Cell study: HepG2, Hep3B, C2C12, L6, Ins, primary cells etc.
Exercise model
siRNA, adenoviral gene transfer
Confocal microscopy, immunohistochemistry
Apoptosis assay, Chromatin immunoprecipitation, EMSA, luciferase assay
microRNA technique

Lab.

연구실사이트 바로가기
Location of Office 의대본관 3층 내분비검사실 내 연구실
Location of Lab. 의대본과 3층 특수검사실 내분비검사실 내
Contact person Name: 강샛별(석사4학기) / Tel: 2228-2833 / E-mail: hb4014@yuhs.ac

Major Published Articles and Books

1) Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by PPARγ agonists. Am J Physiol Endocrinol Metab. 289(1):E151, 2005

2) Depot-specific regulation of perilipin by rosiglitazone in a diabetic animal model. Metabolism 56:676, 2007

3) Rosiglitazone and fenofibrate improve insulin sensitivity of pre-diabetic OLETF rats reducing malonyl-CoA levels in the liver and skeletal muscle. Life Science 84:688, 2009

4) Effect of ABCA1 variant on atherogenic dyslipidemia in patients with type 2 diabetes treated with rosiglitazone. Diabetic Med 26:577, 2009

5) Effect of saturated and monounsaturated fat consumption on the insulin signaling pathway in skeletal muscle of a diabetic animal model. Lipid (in press)