박상욱 / PARK, Sahng Wook
부교수

Department / Institute / Center :
Biochemistry and Molecular Biology
Institute of Genetic Science
Brain Korea 21 Project
만성대사성질환연구센터

Contact Information

Phone +82-2-2228-1694 Email swpark64@yuhs.ac Website

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1988
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 1997
Overseas Training (Institute, Supervisor) Department of Molecular Genetics, Univ. Texas Southwestern Medical Center (Jay D. Horton, MD, 2001-2004)

Professional Societies and current positions

대한생화학분자생물학회 운영위원, 대의원, 1997-현재
Yonsei Med J, Editorial Board, 2010-현재

Research Area(s)

Basic research, Translational research, Clinical research, Drug trial
Research Field Metabolism of LDL-cholesterol
Regulation of PCSK9 expression
Identification of inhibitors of PCSK9 targeting hypercholesterolemia treatment
Diseases Hypercholesterolemia, diabetes, fatty liver disease, cardiovascular disease
Possible Collaboration 고콜레스테롤혈증 치료제 개발
죽상경화증 및 심혈관계질환 관련 연구
비만, 당뇨, 대사성질환 관련 연구

Research Methods

In vivo mouse experiment
Transient transfection, Western blot analysis, siRNA, quantitative real-time PCR,
LDL uptake analysis, reporter assay, Analysis of lipoprotein profile using FPLC

Lab.

연구실사이트 바로가기
Location of Office 의대신관 501호
Location of Lab. 의대신관 505호
Contact person Name: 이현숙 (조교) / Tel: 2228-1695, 1696 / E-mail: hsook1982@yuhs.ac

Major Published Articles and Books

1. Chai-Wan Kim, Young-Ah Moon, Sahng Wook Park, Dong Cheng, Hyock Joo Kwon, Jay D. Horton. 2010. Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. Proceedings of the National Academy of Sciences, U.S.A. 107: 9626-9631
2. Bin Dong, Minhao Wu, Hai Li, Fredric B. Kraemer, Khosrow Adeli, Nabil G. Seidah, Sahng Wook Park, Jingwen Liu. 2010. Strong induction of PCSK9 gene expression through HNF1α and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters. Journal of Lipid Research 51: 1486-1495
3. Hai Li, Bin Dong, Sahng Wook Park, Hyun-Sook Lee, Wei Chen, Jingwen Liu. 2009. Hepatocyte nuclear factor 1α plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine. Journal of Biological Chemistry 284: 28885-28895
4. Min-Young Lee, Jong-Seok Moon, Sahng Wook Park, Yoo-kyung Koh, Yong-Ho Ahn, Kyung-Sup Kim. 2009. KLF5 enhances SREBP-1 action in androgen-dependent induction of fatty acid synthase in prostate cancer cells. Biochemical Journal 417: 313-322
5. Hyun Jeong Jeong, Hyun-Sook Lee, Kyung-Sup Kim, Yoon-Kyoung Kim, Dojun Yoon, and Sahng Wook Park. 2008. Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol regulatory element-binding protein-2. Journal of Lipid Research 49:399-409