윤호근 / YOON, Ho-Geun
부교수

Department / Institute / Center :
Biochemistry and Molecular Biology

Contact Information

Phone +82-2228-1683 Email yhgeun@yuhs.ac Website www.ysf6.org

Educational Background

Undergraduate Education BS., Korea University, 1994
Final Degree (University, Major) Ph.D., Korea University, 2000
Overseas Training (Institute, Supervisor) Baylor College of Medicine, Dept. Mol Cell Biol
(Jiemin Wong, Ph.D., 2001-2005

Professional Societies and current positions

Journal of Medicinal Food, Editor, 2010-현재
The Protein Society, Member, 2009-현재
American Society for Cell Biology, Member, 2008-현재

Research Area(s)

Basic research, Translational research
Research Field Role of transcriptional corepressor complex in tumorigenesis
Development of histone deacetylase 3-specific inhibitor for ant-cancer molecule
Development of histone acetyltransferase inhibitors for anti-inflammatory drugs
The role of histone deacetylase 3 complex in cell death
Diseases Cancer, Alzheimer, Parkinson, Asthma

Possible Collaboration Epigenetic 조절 효소들이 매개하는 종양화 기전 규명
항암제에 대한 암세포의 저항성 기전 규명 및 치료표적 발굴
종양형성 관련 신규 후성유전학효소 발굴
후성유전학 효소 저해제 기반 질환치료제 개발

Research Methods

Protein complex isolation
Yeast-two hybrid assay
Gene knocking-down system
Xenograft 제작 및 in vivo tumorigenecity 측정
Chromatin Immunoprecipitation
Live cell imaging analysis

Lab.

연구실사이트 바로가기
Location of Office 의대 신관 501호
Location of Lab. 의대신관 501호
Contact person Name: 이미희(석사1학기 / Tel: 2228-1684 / E-mail: smile2mh@hanmail.net

Major Published Articles and Books

1) Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor. Choi KC, Park S, Lim BJ, Seong AR, Lee YH, Shiota M, Yokomizo A, Naito S, Na Y, Yoon HG. Biochem J. 2011 14; 433(3):535.
2) HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells. Kim HC, Choi KC, Choi HK, Kang HB, Kim MJ, Lee YH, Lee OH, Lee J, Kim YJ, Jun W, Jeong JW, Yoon HG. Cell Mol Life Sci. 2010. 67(20):3499-510.
3) Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation. Choi KC, Jung MG, Lee YH, Yoon JC, Kwon SH, Kang HB, Kim MJ, Cha JH, Kim YJ, Jun WJ, Lee JM, Yoon HG. Cancer Res. 2009 69(2): 583-92.
4) Function of multiple Lis-Homology domain/WD-40 repeat-containing proteins in feed-forward transcriptional repression by silencing mediator for retinoic and thyroid receptor/nuclear receptor corepressor complexes. Choi HK, Choi KC, Kang HB, Kim HC, Lee YH, Haam S, Park HG, Yoon HG. Mol Endocrinol. 2008 22(5): 1093-104.
5) N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J. Mol Cell. 2003 12(3): 723-34.