김호성 / KIM, Ho-Seong
교수

Department / Institute / Center :
Pediatrics (Pediatric endocrinology)
내분비연구소

Contact Information

Phone +82-2-2228-2069 Email kimho@yuhs.ac Website www.yonseipedi.com

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1984
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 1995
Overseas Training (Institute, Supervisor) Oregon Health Sciences Univ, Dept. Pediatrics
Ron G. Rosenfeld, MD, PhD,. 1995-1997
Youngman Oh, PhD 1999-2003

Professional Societies and current positions

대한소아과학회, 고시위원, 1991-현재
대한내분비학회, 정회원, 1991-현재
대한당뇨병학회, 정회원, 1991-현재
대한소아내분비학회, 부회장, 2008-현재
미국 The Endocrine Society, 정회원, 1997-현재

Research Area(s)

Basic research, Translational research, Clinical research, Drug trial
Research Field Mechanisms of biological action of IGFBP-3
Association of IGFBP-3 in the pathogenesis of diabetic complication
Effect of proteolytic fragment of IGFBP-3 on insulin resistance
Regeneration of pancreatic -cell by incretin
kisspeptin and GPR54 expression in central precocious puberty
Role of endocrine disrupting chemicals in central precocious puberty
Diseases Short stature, T1DM, obesity, precocious puberty
Possible Collaboration IGF-I과 IGFBP-3가 노화에 미치는 영향
비만이 insulin resistance를 일으키는 기전발굴
IGFBP-3가 diabetic complication에 미치는 영향
IGFBP-3와 IGFBP-3 receptor의 암세포 억제효과

Research Methods

Breast cancer cell culture
3T3-L1 preadipocyte culture and differentiation
Western immunoblot, Northern blot,
Real-time RT PCR
siRNA, shRNA, retroivirus, adenoviral gene transfer
Confocal microscopy, immunohistochemistry
FACS analysis, apoptosis assay
luciferase assay
Recombinant protein preparation
Patch clamp study

Lab.

연구실사이트 바로가기
Location of Office 의대본관 445호
Location of Lab. 강남임상의학연구센터 6층
Contact person Name: 이우정(연구원) / Tel: 010-8792-0129 / E-mail: wjlee798@yuhs.ac

Major Published Articles and Books

1) Biological roles of insulin-like growth factor binding proteins (IGFBPs). Kim H-S, Rosenfeld RG, Oh Y. Exp Mol Med 1997;29:85-96.
2) Identification of low-affinity insulin-like growth factor binding proteins (IGFBPs): Characterization of connective tissue growth factor as a member of the IGFBP superfamily. Kim HS, Nagalla SR, Oh Y, Wilson E, Roberts CT Jr, Rosenfeld RG. Proc Natl Acad Sci USA 1997;94:12981-6.
3) Insulin-like growth factor binding protein-3 induces caspase-dependent apoptosis through a death-receptor mediated pathway in MCF-7 human breast cancer cells. Kim H-S, Ingermann AR, Tsubaki J, Twigg SM, Oh Y. Cancer Res 2004;164:2229-37.
4) Insulin-like growth factor binding protein-3 induces G1 cell cycle arrest with inhibition of cyclin-dependent kinase 2 and 4 in MCF-7 human breast cancer cells. Kim HS, Lee SW, Chae HW, Kim DH, Oh Y. Horm Metab Res 2010;42:165-72.
5) Identification of a novel cell death receptor mediating IGFBP-3-induced antitumor effects in breast and prostate cancer. Ingermann AR, Yang YF, Han J, Mikami A, Garza AE, Mohanraj L, Fan L, Idowu M, Ware JL, Kim HS, Lee DY, Oh Y. J Biol Chem 2010;285:30233-46.