박국인 / PARK, Kook In
교수

Department / Institute / Center :
Pediatrics (Neonatology)
Severance Children’s Hospital
Yonsei Brain Institute

Contact Information

Phone +82-2-2228-2059 Email kipark@yuhs.ac Website

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1982
Final Degree (University, Major) Ph.D., Graduate School, Yonsei University, 1992
Overseas Training (Institute, Supervisor) Harvard Medical School, Dept. of Neurology, Division of Neuroscience, Evan Y Snyder, MD, PhD, 1994-1997

Professional Societies and current positions

대한신생아학회, 이사, 1993-현재
Society for Neuroscience, member, 1995-현재
International Society of Stem Cell Research, member, 2003-현재
Korean Society for Tissue Engineering & Regenerative Medicine, 이사, 2004-현재
Korean Society of Neurodegenerative disorders, 이사, 2006-현재

Research Area(s)

Translational research, Clinical research, Other(Neural stem cells)
Research Field - Establishment & characterization of neural stem cells
- Mechanisms on proliferation & differentiation of neural stem cells
- Development of cell therapy & cell based gene therapy for neurological disorders by using human neural stem cells
- Development of fusion technology with neural stem cells, NT and ET for therapeutic applications
- Clinical trials of cell therapy for neurological disorders
Diseases Hypoxic-ischemic brain injury in newborn infants, stroke, epilepsy, Alzheimer’s disease, malignant brain tumor, spinal cord injury
Possible Collaboration - Clinical trial of human neural stem cell transplantation in neurological disorders
- 인간 신경줄기세포의 증식 및 분화기전 및 유도연구
- 난치성 신경계질환 및 뇌종양에서 인간 신경줄기세포를 이용한 세포치료 및 유전자치료 연구 개발
- 유도전분화능 세포 혹은 리프로그래밍 세포 개발 및 활용 연구
- 인간 신경줄기세포와 나노테크놀로지 융합연구를 통하여 세포치료, 나노치료, 유전자치료, 영상기술 개발 연구
- 줄기세포에 대한 모든 기초 및 translational research

Research Methods

- mouse and human neural stem cells culture
- induction of differentiation of neural stem cells
- transplantation of neural stem cells
- development of animal models of neurological disorders
- immunohistochemistry, epifluorescent microscope, confocal microscope
- siRNA, shRNA, lentivirus, adenoviral gene transfer
- FACS analysis, apoptosis assay, ELISA, PCR, western blot

Lab.

연구실사이트 바로가기
Location of Office 의대 본관 438호
Location of Lab. 임상의학연구센터 317호
Contact person Name: 김일선 / Tel: 2228-2805 / E-mail: whitesnown7@yuhs.ac

Major Published Articles and Books

1) T1 and T2 Dual-mode MRI Contrast Agent for Enhancing Accuracy by Engineered Nanomaterials. ACS Nano 2014; 8(4):3393-3401.
2) Exchange-coupled magnetic nanoparticles for efficient heat induction. Nat Nanotechnol 2011; 6(7): 418-22.
3) Direct reprogramming of human neural stem cells by OCT4. Nature 2009; 461(7264):649-653.
4) Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nat Med 2007;13;439-447.
5) Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1{alpha}/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci USA 101(52):18117-18122
6) The injured brain interacts reciprocally with scaffolds seeded with neural stem cells to reconstitute lost tissue. Nat Biotech 2002;20(11):1111-1117.
7) Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci USA 2002;99(5):3024-3029.