이민구 / LEE, Min Goo
교수

Department / Institute / Center :
Department of Pharmacology
Pharmacogenomic Research Center for Membrane Transporters

Contact Information

Phone +82-2-2228-1737 Email mlee@yuhs.ac Website pgx.yonsei.ac.kr

Educational Background

Undergraduate Education M.D., Yonsei University College of Medicine, 1990
Final Degree (University, Major) Ph.D. (Pharmacology Major), Graduate School, Yonsei University, 1996
Overseas Training (Institute, Supervisor) University of Texas Southwestern Medical School, Dept. of Physiology, Shmuel Muallem, Ph.D., 1996-1999

Professional Societies and current positions

Pharmacogenomic Research Center for Membrane Transporters, Director, 2003-present
American Physiological Society, Regular Member, 1998-present
American Gastroenterological Association, Regular Member, 2005-present
Korean Academy of Science and Technology, Young Member, 2002-present
Cell Calcium, Editor, 2009-present

Research Area(s)

Basic research, Translational research
Research Field Role of ion channels and transporters in epithelial transport
Regulation of ion channels and transporters by kinases and PDZ-based adaptors
Molecular and physiological mechanism of pancreatic bicarbonate secretion
Single nucleotide polymorphism (SNP) data integration and analysis for drug response biomarker
Pharmacogenetic studies on drug transporters
Diseases Acute/Chronic pancreatitis, Secretory diarrhea, Pendred syndrome, Drug Response

Possible Collaboration Biochemical and physiological characterization of ion channels, transporters, and their regulatory proteins
Identification of drug targets and new drug development based on molecular mechanism
Molecular and biochemical effect of genetic variations on drug transporters

Research Methods

Human & mouse pancreatic acinar & duct cell isolation and functional analysis
Confocal microscopy (Immunocytochemistry & immunohistochemistry)
TIRF microscopy
Knockout & transgenic mouse experiment
Recombinant protein preparation
Patch clamp study, Intracellular calcium and pH measurement
Pharmacogenetic and statistical analysis of SNPs
FACS analysis
Drug transporter vesicle preparation and transport assay
EMSA, luciferase assay

Lab.

연구실사이트 바로가기
Location of Office 의대신관 302호
Location of Lab. 의대신관 302호
Contact person Name: 김소원 (통합 7학기) / Tel: 2228-2687 / E-mail: hellosw@yuhs.ac

Major Published Articles and Books

1. Articles
① Park, H.W., Nam, J.H., Kim, J.Y., Namkung, W., Yoon, J.S., Lee, J.S., Kim, K.S., Viktoria Venglovecz, Michael A. Gray, Kim, K.H. and Lee, M.G. Dynamic Regulation of CFTR Bicarbonate Permeability by [Cl-]i and its Role in Pancreatic Bicarbonate Secretion, Gastroenterology. 2010;139(2):620-631
② Gee, H.Y., Kim, Y.W., Jo, M.J., Namkung, W., Kim, J.Y., Park, H.W., Kim, K.S., Kim, H.G., Baba, A., Yang, J.H., Kim, E.J., Kim, K.H., and Lee, M.G. Synaptic Scaffolding Molecule Binds to and Regulates Vasoactive Intestinal Polypeptide Type-1 Receptor in Epithelial Cells. Gastroenterology. 2009;137(2):607-617
③ Namkung, W., Kim, K.H., Lee, M.G. Base treatment corrects defects due to misfolding of mutant CFTR. Gastroenterology. 2005;129(6):1979-1990
④ Lee, J.H., Choi, J.H., Namkung, W., Hanrahan, J.W., Chang, J., Song, S.Y., Park, S.W., Kim, D.S., Yoon, J.H., Suh, Y., Jang, I.J., Nam, J.H., Kim, S.J., Cho, M.O., Lee, J.E., Kim, K.H., Lee, M.G. A haplotype-based molecular analysis of CFTR mutations associated with respiratory and pancreatic diseases. Hum. Mol. Genet.2003;12(18):2321-2332.
2. Books
① Lee, M.G., Muallem, S. (2008) Physiology of Duct Cell Secretion, In Berger H. et al, The pancreas: a clinical and surgical text 2nd ed. Chap 7. pp 78-90 (ISBN-10:1405146648), Blackwell Publishing, New York.